MASTER OF SCIENCE

Veterinary Vaccine Production and Quality Control

Course title

Core / Required / Elective

Hours of Lecture

Hours of Practical

Total Hour

Course Unit

FIRST SEMESTER

PVP711 Advanced Bacteriology

C

15

90

105

3

PVP713  Advanced Virology

C

15

90

105

3

PVP715 Molecular biology

R

30

0

30

2

PVP717 Mycology

R

15

90

105

3

PVP719 Advanced Immunology

C

30

45

75

3

PVP 701 Microbes in our environment

E

15

45

60

2

PVP721 Advanced Parasitology

R

15

45

75

2

TOTAL

 

 

 

 

18

SECOND SEMESTER

PVP710 Vaccinology & Vaccine quality control

C

15

45

60

2

PVP712 Viral Vaccine Production

C

30

45

75

3

PVP714 Bacterial Vaccine Production

C

30

45

75

3

PVP716 Quality Management system & Laboratory Animal Management

C

30

45

75

3

PVP718 Research Methods and Experimental Design 

R

30

0

30

2

PVP722 Handling and Shipment of dangerous goods / Cold Chain

R

30

0

30

2

PVP 702 Laboratory Biosafety and Biosecurity

R

15

45

 

2

PVP704 Vaccine registration  process

R

30

0

30

2

TOTAL

    

19

THIRD SEMESTER

PVP721 Internship in Veterinary Vaccine Production and Quality Control

C

0

270

270

6

TOTAL

    

6

FOURTH SEMESTER

PVP720  Seminar:

C

30

0

30

2

PVP724 Project:

C

0

270

 

6

TOTAL

    

8

 

Veterinary Vaccine Production and Quality control courses

S/no.

Course Code

Course Title

Credit Unit

Course Status

1

PVP710

Vaccinology and Quality Control of Vaccines 

2

C

2

PVP711

Advanced Bacteriology

3

C

3

PVP712

Viral Vaccine Production   

3

C

4

PVP713

Advanced Virology      

3

C

5

PVP714

Bacterial Vaccine Production 

3

C

6

PVP715

Molecular Biology 

2

R

7

PVP716

Quality management system and laboratory Animal management

3

R

8

PVP717

Advanced Mycology

3

R

9

PVP718

Research Methods and Experimental Design 

2

R

10

PVP719

Advanced Immunology

3

C

11

PVP720

Seminar 

2

C

12

PVP721

Internship in Vaccine Production

6

C

13

PVP722

Handling and shipping of dangerous good/ Cold chains

2

R

14

PVP724

Project: 

6

C

15

PVP701

Microbes in our environment 

2

E

16

PVP702

Laboratory Biosafety and Biosecurity

2

R

17

PVP 703

Advanced Parasitology

2

R

18

PVP 704

Vaccine Registration Process

2

R

 

SYLLABUS


PVP710 VACCINOLOGY [3 C.U]

Course description:  

This course will involve series of lectures on vaccine, vaccine development and its use.

Course purpose: 

This course will provide students with in-depth knowledge on vaccine development and mechanism of vaccine protection.

Course topics:

  • History of vaccination
  • Type of Vaccines
  • Pathway to vaccine development
  • Mechanism of vaccine protection
  • Vaccine construction
  • Measurement to immune response to vaccination
  • Vaccine efficacy and safety
  • Adjuvant  in making vaccines immunogenic
  • DNA vaccines

PVP711 ADVANCED BACTERIOLOGY [3 C.U]

Course description:

This course will provide an overview of bacteria of Veterinary importance at an advanced level.

Course purpose:

To equip the students with knowledge in bacteriology for use in bacterial vaccine production and quality control.

Course topics:

  • General principle of bacteria taxonomy
  • Classification of bacteria
  • Characteristics and structures of bacteria
  • Overview of bacterial diseases of animals including zoonosis
  • Emerging and re-emerging bacterial diseases of domesticated and wild animals
  • Bacterial genetics
  • General biochemical background of bacteria.
  • Isolation and Identification methods of common bacteria of veterinary importance.
  • Pathogenesis of bacterial diseases including molecular basis of host-bacterial relationship.

Recommended text:

  1. Microbiology by Simon Baker et al. Tailor and Francis (Publisher)
  2. Medical Microbiology by Robert Cruikshank et al. Churchill Livingstone Edinburgh
  3. Text-Book of Bacteriology by Carl Fraenkel. Forgotten Books, 2012
  4. Journal of Bacteriology

PVP712 VIRAL VACCINE PRODUCTION [3 C.U]

Course Description:

This course will provide a step by step teaching on viral vaccine production.  

Course purpose:

Students will acquire theoretical knowledge and practical skills in viral vaccine production.

Course topics:

  • Preparation of seed virus stock
  • Generation of viral sub-units and antigens
  • Inactivation/Purification of viral antigens
  • Formulation of viral vaccine.
  • Lyophilisation processes
  • Product purity, safety and potency testing.  
  • Packaging

Recommended text:

  1. Vaccines (Sixth edition). ISBN: 978-1-4557-0090-5 Copyright @ 2017 Elsevier B. V.
  2. The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers and Government Neglect. ISBN – 13: 978-0312342722: ByDebbie Bookchin& Jim Schumacher
  3. Influenza and Influenza Vaccine: by Raymond A. Strikas, MD, MPH; CDC, (Pink Book) webinar series, September 7, 2016

PVP713 Advanced Virology [3 C.U]

Course description:

This involves teaching of viruses, animal diseases and laboratory methods used for diagnosis.

Course purpose:

To prepare students with knowledge in the manipulation of viruses for vaccine production and quality control.

Course topics:

  • Understanding the principle and uses of different medium for viral cultivation
  • Classification of viruses
  • Characteristics and structures of viruses.  
  • Isolation, cultivation, replication, concentration and purification of viruses.   
  • Pathogenesis of viral diseases including molecular basis of host-viral relationship
  • Serological, molecular and other techniques used for viral identification.

Recommended text:

  1. Fields VIROLOGY. David M. Knipe et al (Editors). By Lippincott Williams & Wilkins.
  2. A Concise Review of Veterinary Virology D.J. Wise, G.R. Carter and E. F. Flores
  3. Cunningham, C. H. (latest edition).  ALaboratoryGuideinVirology, 7th ed. Burgess Minneapolis MN.
  4. Journal of Virology

PVP714 BACTERIAL VACCINE PRODUCTION [3 C.U]

Course description:

To provide the student with detailed processes on bacterial vaccine production

Course purpose:

To enable students have theoretical knowledge and practical exposure in bacterial vaccine production

Course topics:

  • Preparation of seed bacteria stock
  • Generation of bacterial sub-units and antigens
  • Inactivation/Purification of bacterial antigens
  • Formulation of the vaccine.
  • Lyophilisation processes
  • Product purity, safety and potency testing.  
  • Packaging and storage

Recommended Text:

  1. Bacterial Vaccines: Edited by Rene Germanier, Academic Press
  2. The Vaccine Book: Edited by Barry R. Bloom and Paul-Henri Lambert, Academic Press
  3. Vaccines for Biodefense and Emerging and Neglected Diseases: By Alan D. T. Barrett & Lawrence R. Stanberry. Academic Press

PVP715 MOLECULAR BIOLOGY AND BIOINFORMATICS [2 C.U]

Course description:

This course provides knowledge onmolecular basis of existence of microbes and bioinformatics

Course purpose:

To enable students understand molecular basis of microbial genetic activities in relation to vaccine production and quality control.

To impact knowledge in bioinformatics for microbial analysis and manipulations.

Course topics:

  • The central dogma
  • Growth and its control, genetic organization of the organisms’ protein production
  • The use of PCR and DNA/RNA sequencing.
  • Recombinant DNA technology
  • Bioinformatics: Application of Bioinformatics  Bioinformatic Software and data manipulation, GenBank, Nucleic acid amplification and sequencing, use of Gene Sequences Analysis software (BioEdit®, MEGA, CLC etc), Phylogenetic tree construction and analysis.

Recommended Text:

  1. Molecular Cell Biology: (Lodish, Molecular Cell Biology) by Lodishet al.
  2. Molecular Biology of the Cell: 5th Edition. ISBN – 13: 978-0815341055
  3. “The Sequence:” by Kevin Davies [Weidenfeld; ISBN 0297646982
  4. Bioinformatics Algorithms: An Active Learning Approach Vol. 1&2 by Phillip Compeau and Pavel Pevzner

PVP716 LABORATORY ANIMAL AND QUALITY MANAGEMENT SYSTEM [3 C.U]

Course description:

This course provides teaching on the application of laboratory quality management system and animal care.

Course purpose:

At the end of the course, student will be familiar with the implementation of quality laboratory operations.

Course topics:

  • Introduction to quality manual.
  • Quality policy
  • Organization
  • Management of Lab equipment
  • Purchasing and inventory
  • Process management
  • Assessment/audit
  • Customer focus

Recommended text:

  1. WHO quality manual 2013
  2. Management of Laboratory Animal Care and Use Programs: Edited by Mark A. Suckow, Fred  A. Douglas and Robert H. Weichbrod; CRC